|
KMID : 0604519980240030089
|
|
Journal of the Society of Cosmetic Scientists of Korea
1998 Volume.24 No. 3 p.89 ~ p.95
|
|
|
PREPARATION OF MULTIFUNCTIONAL LOW MOLECULAR WEIGHT CHITOSAN AND ITS APPLICATION IN COSMETICS
|
|
Ryu, Chang-Suk
Kim Hyung-Bae
Kim Jeong-Ha
Cho Byung-Ki
Suh Sang-Bong
|
|
|
Abstract
|
|
|
|
The aim of this study is to elucidate the anti-microbial activity and anti-oxidative activity of water-soluble chitosan with a molecular weight of 5,000-200,000. Water-soluble chitosans have demonstrated a regular anti-microbial activity on the tested strians by the paper disk method. In the MIC (Minimum Inhibitory Concentration) test, CC-01 (MW=5,000) with the lower MW showed the higher MIC value than the higher MW chitosan. The MW of chitosan increase, the MIC decreases. MICs of 4 chitosans(CC-02∼CC-05) against S. aureusTCC 65389, E coli ATCC 8739, p. aeruginosa, ATCC 9027 and C. albicans ,ATCC 10231 were 7.0-39.Omutextrm{m}, whereas MICs of chitosans against A. niger were over 2.OmM. Formula containing chitosan showed higher anti-microbial activities than the formula made with the chemical preservatives(Methylparaben 0.2％ and Imidazolidinyl Urea 0.3％). Among 5 water-soluble chitosans, CC-03(MW=92,163) showed the most potent anti-oxidative activity (ICsub50/ : 0.2mM). In conclusion, the water-soluble low molecular weight chitosan could be served as natural preservatives and antioxidant in cosmetics.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|